Introduction and application of synthesis and storage method of 2-aminothiazole from chinahutong's blog

synthesis and storage method of 2-aminothiazole is a chemical substance with the molecular formula C6H7N and molecular weight 93.126.

synthesis and storage method of 2-aminothiazole is a homologue of pyridine, which is an aromatic hydrocarbon and also a six-membered ring. It is similar to benzene in some respects, but different from benzene. For example, toluene has no isomer, The synthesis and storage method of 2-aminothiazole has three isomers. Namely, 2-synthesis and storage method of 2-aminothiazole[1], 3-synthesis and storage method of 2-aminothiazole[2] and 4-synthesis and storage method of 2-aminothiazole[3]. Its molecular weight is 93.13. It exists naturally in coal tar and has active chemical properties. It can react with side chain oxidation and nitrogen substitution, or condensation with aldehydes and ketones under alkali catalysis.

[1] Also known as α-synthesis and storage method of 2-aminothiazole and α-picoline. Colorless liquid. It has a strong pungent odor. Relative density 0.9462. Melting point -66.8℃. The boiling point is 128.8℃. Refractive index 1.4957. Flash point 26℃. Soluble in water and acetone, miscible with ethanol and ether. Composed of azeotrope with water, the content of this product is 52%, the boiling point is 93.5℃. Rat transoral LD501410 mg/kg.

Purpose: Raw material for the production of 2-vinylpyridine; Pesticide raw materials, production of "azoxadine", "pyridine-2, 5-dicarboxylate", "diphloridine", "chloridine", "dioxypicolinic acid", "methyliodide - 2-pyridinaldoxime", "toxatrazine" and so on.

[2] Also known as the β-synthesis and storage method of 2-aminothiazole and β-picoline. Colorless and transparent liquid. It has a pungent odor. The taste is slightly sweet. The relative densities are 0.9560 and 0.9613(15℃). Melting point -18.3℃. Boiling point 143.9℃. Refractive index 1.5403. Flash point 36℃(closed). Miscible with water, ethanol and ether. This product is composed of azeotrope with water. The content of this product is 27% and the eutectic point is 96.7℃. Unlike [1] and [3], this product has poor methyl reactivity. Has a stimulating effect on the skin, can also be absorbed through the skin, its vapor stimulates the eyes and respiratory tract, cause inflammation, serious cause blisters, vomiting, headache and other symptoms. Rat transoral LD50790mg/kg.

Uses: pesticide raw materials, the production of herbicides, insecticides, fungicides, such as "protonicotinoid", "benzopyriol" and rodenticide "antirhamine"; Food additives: 2-synthesis and storage method of 2-aminothiazole is added during meat processing to combine with myoglobin, which can prevent oxidation and keep the color of meat fresh. When [2] is added to bread, pastries, rice products, dairy products, ham, sausage and other foods, it can play the role of vitamin strengthening medicine, and can be used instead of vitamin B. As a vitamin fortification agent can be added to infant milk powder, women's pregnancy milk powder, food and drink; It can also be used as medicine to treat niacin deficiency; Feed additive; Producing niacinamide or replacing it; Alcohol modifier; Dye intermediate; Rubber vulcanizing agent and film sensitizer raw materials, etc.

[3] Also known as gamma-synthesis and storage method of 2-aminothiazole and gamma-picoline. Colorless liquid. It has flammability. There is an unpleasant smell. It's sweet. If impurities are mixed in, the color gradually turns yellow. Relative density 0.9558. Melting point 3.7℃. Boiling point 144.9℃. Refractive index 1.5064(17℃). Flash point 56℃. Soluble in water, ethanol and ether. This product forms an azeotrope with water, the content of this product is 63.5%, the eutectic point is 97.4℃. It is irritating to the skin, eyes and mucous membranes. Because of the stench, it can be felt even if the concentration is 1×10-6 and can be prevented as soon as possible. After poisoning, nausea, vomiting, headache, serious can cause viscera and nerve z-axis disease. Rat transoral LD501290mg/kg.

Uses: medical raw materials, production of tuberculosis medicine "isoniazid", anti-depressant "niacidamide", antidote "diphos"; Pesticide raw materials, production of insecticides and herbicides; Can also be used for dyes, rubber additives, fabric waterproof agent, resin curing agent; It is the raw material of niacinaldehyde, 2-amino-4-synthesis and storage method of 2-aminothiazole(veterinary drug), pyridine-4-carboxylic acid (anticoagulant), etc.

synthesis and storage method of 2-aminothiazole https://www.clentpharma.com/2-Aminothiazole.html